The NYC Health and Nutritional Examination Survey (NYC HANES), modeled on the National Health and Nutrition Examination Survey (NHANES), is a population-based, cross-sectional study with data colleced from physical examinations, clinical and laboratory tests, as well as face-to-face interviews and audio computer-assisted self-interviews (ACASI). It was first conducted in 2004 by the NYC Department...

The Framingham Heart Study (FHS) is dedicated to identifying common factors or characteristics that contribute to cardiovascular disease (CVD). In 1948, an original cohort of 5,209 men and women between 30 and 62 years old were recruited from Framingham, MA. An Offspring Cohort began in 1971, an Omni Cohort in 1994, a Third Generation Cohort in 2002, a New Offspring Spouse Cohort in 2004 and a Second...

ALLHAT was a large antihypertensive trial and lipid-lowering trial and included large numbers of patients over age 65, women, African-Americans, and patients with diabetes, treated largely in community practice settings. Participants were men and women aged 55 years and over with a history of hypertension. Data collected includes participant physical measures, demographics, health behaviors, medical...

The Women's Health Initiative (WHI) is a long-term national health study that focuses on strategies for preventing heart disease, breast cancer, colorectal cancer, and osteoporotic fractures in postmenopausal women. The study includes data from 161,808 women aged 50-79. Datasets include information on demographics, diet, medical and physical measurements, medical history, outcomes (both adjudicated...

The Nurses' Health Studies (NHS) are long-running, questionnaire-based studies on women's health. The study was started in 1976 and expanded in 1989 and includes data from 238,000 female, nurse-participants. The study focuses on cancer, cardiovascular disease and risk factors for chronic health issues in women. The dataset includes both survey data and biospecimens.

ACCORD was a large clinical trial examining methods of lowering the rate of cardiovascular disease in adults with type two diabetes. The study was composed of three clinical trials: an intensive lowering of blood sugar levels, intensive lowering of blood pressure, and treatment of multiple blood lipids with a combination of a fibrate and a statin. The study enrolled 10,251 adults beginning in 2001.

The Demographic and Health Surveys (DHS) Program uses nationally representative surveys, biomarker testing, and geographic location to collect data on monitoring and impact evaluation indicators for individual countries and for cross-country comparisons. There are several survey types used, including Demographic and Health Survey, Service Provision Assessment, HIV/AIDS Indicator Survey, Malaria Indicator...

RNA was extracted from FACS-sorted cells at 8 distinct stages of erythropoiesis, derived from CB- and PB-CD34+ cells. cDNA libraries were prepared using the Illumina TruSeq kit and sequenced on the Illumina HiSeq 2500 (Epigenomics Core of Weill Cornell Medical College, New York). This sequencing strategy produced ~15-80 million 50bp single end reads per sample. For each distinct stage of erythropoiesis,...

Biological triplicates of peripheral blood (PB)- and cord blood (CB)-derived colony-forming unit-erythroids (CFU-Es) were treated in the absence or presence of dexamethasone (100 nM) for 24 hours. These cells were then processed for proteomics analysis by liquid chromatography–tandem mass spectrometry (LC-MS/MS). Proteomics quantified 10,045 proteins in PB samples and 10,028 proteins in CB samples....

The NIH Rapid Acceleration of Diagnostics Data Hub (RADx® Data Hub) supports researchers in accessing curated and de-identified COVID-19 data, allowing them to find, aggregate, and perform data analyses in a cloud-enabled platform. The RADx Data Hub supports efforts to understand COVID-19 and factors associated with disparities in COVID-19 morbidity and mortality in underserved and vulnerable populations....