ZSOM Data Catalog

Authors: Arnon Arazi

Deepak A. Rao

Celine Berthier

Anne Davidson

39 more author(s)...
Description: Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed kidney samples from patients with lupus nephritis and from healthy control subjects using single-cell RNA sequencing. Our analysis revealed 21 subsets of leukocytes active in disease, including multiple populations of myeloid...
Subject: Kidney

Lupus Nephritis

RNA-Seq

Sequence Analysis, RNA
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Local Expert: Anne Davidson

Arnon Arazi

Betty Diamond

Authors: Mustafa Ghanem

Andrew Shih

Houman Khalili

Emily Werth

4 more author(s)...
Description: Plasmacytoid dendritic cells (pDCs) represent a rare innate immune subset uniquely endowed with the capacity to produce substantial amounts of type-I interferons (IFN-I). This function of pDCs is critical for effective antiviral defenses and has been implicated in autoimmunity. While IFN-I and select cytokines have been recognized as pDC secreted products, a comprehensive agnostic profiling of the...
Subject: Influenza A Virus, H1N1 Subtype

Interferon Type I

Proteomics

RNA-Seq
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Local Expert: Andrew Shih

Peter Gregersen

Description: The Cancer Genome Atlas (TCGA), a landmark cancer genomics program, molecularly characterized over 20,000 primary cancer and matched normal samples spanning 33 cancer types. This joint effort between NCI and the National Human Genome Research Institute began in 2006, bringing together researchers from diverse disciplines and multiple institutions. Over the next dozen years, TCGA generated over 2.5...
Subject: Cancer

Genome, Human

Genomics
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Local Expert: Nyasha Chambwe

Authors: Rakesh Mishra

Ramalingam Bethunaickan

Celine Berthier

Zhengzi Yi

4 more author(s)...
Description: This study examines the circadian gene expression of whole kidneys of young and nephritic NZB/W F1 mice. Young mice were harvested at 12 weeks of age. Nephritic mice were harvested 2-3 weeks after nephritis onset (>300mg/dl proteinuria) but before the development of endstage renal failure (BUN >25). Remission was induced in nephritic mice with new onset proteinuria of less than 1 week duration measured...
Subject: Lupus Nephritis

mice

RNA-Seq
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Local Expert: Anne Davidson

Patricio Huerta