ZSOM Data Catalog

Authors: Theodoros Zanos

Harold Silverman

Todd Levy

Tea Tsaava

6 more author(s)...
Description: These datasets were generated during a study to develop methods to isolate and decode specific neural signals to discriminate between two different cytokines. Nerve impulses recorded from the vagus nerve of mice exposed to IL-1B and TNF were sorted into groups based on their shape and amplitude, and their respective firing rates were computed. These cytokine-mediated responses were subsequently decoded....
Subject: Electrophysiology

mice

Vagus Nerve

Authors: Anthony Hesketh

Caroline Maloney

Christopher Behr

Morris Edelman

5 more author(s)...
Description: The purpose of this microarray is to identify genes that may be differentially expressed in M1 or M2 macrophages after treatment with CNI-1493. CNI-1493 is a known inhibitor of M1 macrophages but details of its molecular mechanism are unknown. The effect of CNI-1493 on M2 macrophages has yet to be explored, but we hypothesize that CNI-1493 treatment will attenuate pro-tumor properties of M2 macrophages....
Subject: Cancer

Genomics

mice
Access Rights: Free to All
Local Expert: Bettie Steinberg

Authors: Gerard Honig

Simone Mader

Huiyi Chen

Amit Porat

4 more author(s)...
Description: Systemic infection can initiate or exacerbate central nervous system (CNS) pathology, even in the absence of overt invasion of bacteria into the CNS. Recent epidemiological studies have demonstrated that human survivors of sepsis have an increased risk of long-term neurocognitive decline. There is thus a need for improved understanding of the physiological mechanisms whereby acute sepsis affects the...
Subject: mice

Vagus Nerve
Access Rights: Free to All
Local Expert: Betty Diamond

Bruce Volpe

Authors: Siavash Bolourani

Ezgi Sari

Max Brenner

Ping Wang
Description: In order to study the connection of the enrichment of these pathways in priming the microenvironment for pulmonary fibrosis, we investigated the gene expression profile of lung tissues from mice subjected to bleomycin-induced pulmonary fibrosis. The wild type (WT) and TLR4 -/- pulmonary fibroblasts were treated with phosphate-buffered saline (PBS), 1 µg/mL recombinant mouse (rm) CIRP, 2 ng/mL rmTGF-ß1...
Subject: Fibroblasts

Inflammation

mice

Pulmonary Fibrosis
Access Rights: Free to All
Local Expert: Max Brenner

Ping Wang

Authors: Rakesh Mishra

Ramalingam Bethunaickan

Celine Berthier

Zhengzi Yi

4 more author(s)...
Description: This study examines the circadian gene expression of whole kidneys of young and nephritic NZB/W F1 mice. Young mice were harvested at 12 weeks of age. Nephritic mice were harvested 2-3 weeks after nephritis onset (>300mg/dl proteinuria) but before the development of endstage renal failure (BUN >25). Remission was induced in nephritic mice with new onset proteinuria of less than 1 week duration measured...
Subject: Lupus Nephritis

mice

RNA-Seq
Access Rights: Free to All
Local Expert: Anne Davidson

Patricio Huerta

Authors: Siavash Bolourani

Ezgi Sari

Max Brenner

Ping Wang
Description: We examined the role of eCIRP in the pathogenesis of bleomycin-induced pulmonary fibrosis (PF). Publicly available gene expression omnibus datasets were analyzed for the expression of CIRP in lung samples from patients with PF. Wild type (WT) or CIRP-/- mice received daily injections of 10 μg/g bleomycin for 10 days. A subset of bleomycin-injected WT mice was treated with the eCIRP antagonist C23 (8...
Subject: mice

MicroRNAs

Pulmonary Fibrosis
Access Rights: Free to All
Local Expert: Max Brenner

Ping Wang