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ZSOM Data Catalog

Internal Dataset

Murine vagus nerve recordings after cytokine injection

UID: 10368
Author(s): Theodoros Zanos, Harold Silverman, Todd Levy, Tea Tsaava, Emily Battinelli...
* Corresponding Author

Description
These datasets were generated during a study to develop methods to isolate and decode specific neural signals to discriminate between two different cytokines. Nerve impulses recorded from the vagus nerve of mice exposed to IL-1B and TNF were sorted into groups based on their shape and amplitude, and their respective firing rates were computed. These cytokine-mediated responses were subsequently decoded. Datasets contain all neurorecordings from the surface vagus nerve of mice. Matlab code for analysis and algorithms is included.
Subject Domain
Electrophysiology
mice
Vagus Nerve
Keywords
Bioelectronic medicine
Cytokines
Inflammation
Neural decoding
Neural signals
Vagus nerve

Access

Instructions
Link to the local repository where the datasets and analysis code in Matlab reside is provided in the PMC article.
Associated Publications
Zanos, T. P., Silverman, H. A., Levy, T., Tsaava, T., Battinelli, E., Lorraine, P. W., Ashe, J. M., Chavan, S. S., Tracey, K. J., & Bouton, C. E. (2018). Identification of cytokine-specific sensory neural signals by decoding murine vagus nerve activity. Proceedings of the National Academy of Sciences of the United States of America, 115(21), E4843–E4852. https://doi.org/10.1073/pnas.1719083115
Data Type
Electrophysiological
Equipment Used
Bipolar sling platinum-iridium cuff electrode (CorTec)
Plexon data-acquisition system (OmniPlex; Plexon, Inc.)
Software Used
MatLab
Study Type
Interventional
Dataset Format(s)
plx
Dataset Size
82.1 gb
Grant Support
W911NF-09-1-0125/Defense Advanced Research Projects Agency
R35 GM118182-01/National Institute of General Medical Science
General Electric Company/General Electric Company