DepMap
Alternate Titles(s): Cancer Dependency Map
UID: 10394
- Description
- The mutations that cause cancer cells to grow also confer specific vulnerabilities that normal cells lack. Some of these acquired alterations represent compelling therapeutic targets. The challenge is that, for the overwhelming majority of cancers, we do not fully understand the relationship between the genetic alterations of cancer and the dependencies they cause. To solve this problem, we are creating a “cancer dependency map” by systematically identifying genetic dependencies and small molecule sensitivities and discovering the biomarkers that predict them.
DepMap scientists are profiling hundreds of cancer cell line models for genomic information and sensitivity to genetic and small molecule perturbations. By triangulating information from these and other large-scale datasets, the hope is to define a landscape of genetic targets for therapeutic development, identify patients who respond to these therapies, and develop a better understanding of the vulnerabilities of cancer. - Publisher
- Local Expert
Access
- Restrictions
-
Free to AllFree to all with registration
- Instructions
- Data can be downloaded from the DepMap portal. Some tools require registration of a free account.
Observational
- Other Resources
Do you have or know of a dataset that should be added to the catalog? Let us know!