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Results Found: 12

  • Clinical Proteomic Tumor Analysis Consortium Data

    Alternate Title(s)
    CPTAC
    Description

    The Clinical Proteomic Tumor Analysis Consortium (CPTAC) analyzes cancer biospecimens by mass spectrometry, characterizing and quantifying their constituent proteins, or proteome. Proteomic analysis for each CPTAC study is carried out independently by Proteomic Characterization Centers (PCCs) using a variety of protein fractionation techniques, instrumentation, and workflows. Mass spectrometry and...

    Subject
    Cancer
    Genomics
    Access Rights
    Free to All

  • The Cancer Genome Atlas

    Description

    The Cancer Genome Atlas (TCGA), a landmark cancer genomics program, molecularly characterized over 20,000 primary cancer and matched normal samples spanning 33 cancer types. This joint effort between NCI and the National Human Genome Research Institute began in 2006, bringing together researchers from diverse disciplines and multiple institutions. Over the next dozen years, TCGA generated over 2.5...

    Subject
    Cancer
    Genome, Human
    Genomics
    Access Rights
    Free to All
    Local Expert
    Nyasha Chambwe

  • DepMap

    Alternate Title(s)
    Cancer Dependency Map
    Description

    The mutations that cause cancer cells to grow also confer specific vulnerabilities that normal cells lack. Some of these acquired alterations represent compelling therapeutic targets. The challenge is that, for the overwhelming majority of cancers, we do not fully understand the relationship between the genetic alterations of cancer and the dependencies they cause. To solve this problem, we are creating...

    Subject
    Big Data
    Cancer
    Genomics
    Precision Medicine
    Proteomics
    Access Rights
    Free to All
    Free to all with registration
    Local Expert
    Nyasha Chambwe

  • Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes
    Internal Dataset

    Authors
    Catherine Robertson
    Jamie Inshaw
    Suna Onengut-Gumuscu
    Wei-Min Chen
    28 more author(s)...
    Description

    We report the largest and most diverse genetic study of type 1 diabetes (T1D) to date (61,427 participants), yielding 78 genome-wide significant (P < 5 × 10−8) regions, including 36 novel. We define credible sets of T1D-associated variants and show they are enriched in immune cell-accessible chromatin, particularly CD4+ effector T cells. Using chromatin accessibility profiling of CD4+ T cells from...

    Subject
    Alleles
    Chromosome Mapping
    Diabetes Mellitus, Type 1
    Genetic Predisposition to Disease
    Genetic Variation
    Genomics
    Access Rights
    Free to All
    Local Expert
    Peter Gregersen

  • AACR Project GENIE

    Description

    AACR Project GENIE is a publicly accessible international cancer registry of real-world data assembled through data sharing between 19 of the leading cancer centers in the world. Through the efforts of strategic partners Sage Bionetworks and cBioPortal, the registry aggregates, harmonizes, and links clinical-grade, next-generation cancer genomic sequencing data with clinical outcomes obtained during...

    Subject
    Big Data
    Cancer
    Genomics
    Precision Medicine
    Access Rights
    Free to all with registration
    Local Expert
    Nyasha Chambwe

  • Immunoglobulin intraclonal diversification in Chronic Lymphocytic Leukemia tumor cells
    Internal Dataset

    Authors
    Davide Bagnara
    Catherine Tang
    Jennifer Brown
    Siddha Kasar
    15 more author(s)...
    Description

    We used a DNA sequencing approach that achieves considerable depth and minimizes artefacts and amplification bias to identify IGHV-IGHD-IGHJ subclones in patients with prolonged temporal follow-up. Our findings extend previous studies, revealing intraclonal IGHV-IGHD-IGHJ diversification in almost all CLL clones. Also, they indicate that some subclones with additional IGHV-IGHD-IGHJ mutations can become...

    Subject
    Cancer
    Genome, Human
    Genomics
    Access Rights
    Free to All
    Local Expert
    Nicholas Chiorazzi

  • Genome-wide analysis of M1 and M2 polarized macrophages with CNI-1493 treatment
    Internal Dataset

    Authors
    Anthony Hesketh
    Caroline Maloney
    Christopher Behr
    Morris Edelman
    5 more author(s)...
    Description

    The purpose of this microarray is to identify genes that may be differentially expressed in M1 or M2 macrophages after treatment with CNI-1493. CNI-1493 is a known inhibitor of M1 macrophages but details of its molecular mechanism are unknown. The effect of CNI-1493 on M2 macrophages has yet to be explored, but we hypothesize that CNI-1493 treatment will attenuate pro-tumor properties of M2 macrophages....

    Subject
    Cancer
    Genomics
    mice
    Access Rights
    Free to All
    Local Expert
    Bettie Steinberg

  • Differential gene expression analysis of PTGS2-inducing and PTGS2-non-inducing oropharyngeal carcinoma cell lines.
    Internal Dataset

    Authors
    James DeVoti
    Mohd Israr
    Fung Lam
    Christopher Papayannakos
    6 more author(s)...
    Description

    Prostaglandin E2 (PGE2) is a powerful immunomodulator synthesized by the COX2 enzyme, coded by human gene PTGS2. PGE2 is known to possess angiogenic, protumor and immunosuppressive functionality in the microenviornment of oropharyngeal carcinomas (OPC). Differential induction of PTGS2 in infiltrating myeloid-derived immunocytes has been observed with media conditioned by cultured OPC biopsies and OPC-derived...

    Subject
    Cyclooxygenase 2
    Genomics
    Monocytes
    Oropharyngeal Neoplasms
    Access Rights
    Free to All
    Local Expert
    Vincent Bonagura

  • Cholinergic Anti-inflammatory Pathway (CAP) Activation in a Model of Acute Lung Infection
    Internal Dataset

    Authors
    John Graf
    Umair Ahmed
    Anthony Liew
    Annette Lee
    2 more author(s)...
    Description

    The cholinergic anti-inflammatory pathway (CAP), has been well-studied and shown to control peripheral cytokine levels and inflammation. This nerve pathway has been activated pharmacologically or by nerve stimulators and studied in animal models and clinical studies. However, these CAP investigations have typically been performed in models or study populations of severe systemic or pathological inflammation....

    Subject
    Genomics
    Inflammation
    Rats
    RNA-Seq
    Access Rights
    Free to All
    Local Expert
    Stavros Zanos

  • Immune Dysregulation/Tumor-Associated Gene Changes in Recurrent Respiratory Papillomatosis: A Paired Microarray Analysis
    Internal Dataset

    Authors
    James DeVoti
    David Rosenthal
    Rong Wu
    Allan Abramson
    2 more author(s)...
    Description

    The goal of this study was to determine the differential expression of specific genes within the papilloma tissues themselves and to characterize the array of host genes that might be important in the pathophysiology of recurrent respiratory papillomatosis. Total RNAs from papillomas (n=12) and adjacent tissues (n=12) were analyzed by Affymetrix microarray, and the matched sets of tissues compared...

    Subject
    Cancer
    Genomics
    Human Papillomavirus Viruses
    Papilloma
    Access Rights
    Free to All
    Local Expert
    Vincent Bonagura