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DepMap
- Alternate Title(s)
- Cancer Dependency Map
- Description
The mutations that cause cancer cells to grow also confer specific vulnerabilities that normal cells lack. Some of these acquired alterations represent compelling therapeutic targets. The challenge is that, for the overwhelming majority of cancers, we do not fully understand the relationship between the genetic alterations of cancer and the dependencies they cause. To solve this problem, we are creating...
- Subject
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Big DataCancerGenomicsPrecision MedicineProteomics
- Access Rights
- Free to AllFree to all with registration
- Local Expert
- Nyasha Chambwe
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The Cancer Genome Atlas
- Description
The Cancer Genome Atlas (TCGA), a landmark cancer genomics program, molecularly characterized over 20,000 primary cancer and matched normal samples spanning 33 cancer types. This joint effort between NCI and the National Human Genome Research Institute began in 2006, bringing together researchers from diverse disciplines and multiple institutions. Over the next dozen years, TCGA generated over 2.5...
- Subject
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CancerGenome, HumanGenomics
- Access Rights
- Free to All
- Local Expert
- Nyasha Chambwe
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Immunoglobulin intraclonal diversification in Chronic Lymphocytic Leukemia tumor cells
Internal Dataset- Authors
- Davide BagnaraCatherine TangJennifer BrownSiddha Kasar15 more author(s)...
- Description
We used a DNA sequencing approach that achieves considerable depth and minimizes artefacts and amplification bias to identify IGHV-IGHD-IGHJ subclones in patients with prolonged temporal follow-up. Our findings extend previous studies, revealing intraclonal IGHV-IGHD-IGHJ diversification in almost all CLL clones. Also, they indicate that some subclones with additional IGHV-IGHD-IGHJ mutations can become...
- Subject
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CancerGenome, HumanGenomics
- Access Rights
- Free to All
- Local Expert
- Nicholas Chiorazzi
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Subject Domain
- Cancer 3
- Genomics 3
- Genome, Human 2
- Big Data 1
- Precision Medicine 1
- Proteomics 1