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The Immune Cell Landscape in Kidneys of Lupus Nephritis Patients
Internal Dataset- Authors
- Arnon AraziDeepak A. RaoCeline BerthierAnne Davidson39 more author(s)...
- Description
Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed kidney samples from patients with lupus nephritis and from healthy control subjects using single-cell RNA sequencing. Our analysis revealed 21 subsets of leukocytes active in disease, including multiple populations of myeloid...
- Subject
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KidneyLupus NephritisRNA-SeqSequence Analysis, RNA
- Access Rights
- Free to all with registrationApplication Required
- Local Expert
- Anne DavidsonArnon AraziBetty Diamond
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IRF5 genetic risk variants drive myeloid-specific IRF5 hyper-activation and pre-symptomatic SLE
Internal Dataset- Authors
- Dan LiBharati MattaSu SongVictoria Nelson5 more author(s)...
- Description
The IRF5-SLE risk haplotype is associated with SLE disease severity. We hypothesized that neutrophils from healthy risk donors would carry a pathogenic gene signature compared to non-risk donors. To compare basal neutrophil gene signature between risk and non-risk healthy individuals, fresh whole blood was collected from healthy donors, and granulocytes were extracted from the remaining pellet following...
- Subject
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Genetic Predisposition to DiseaseGenetic VariationInterferon Regulatory FactorsLupus Erythematosus, Systemic
- Access Rights
- Free to All
- Local Expert
- Betsy BarnesPeter Gregersen
