-
Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase
Internal Dataset- Authors
- Peder OlofssonMichaela OswaldKevin Tracey
- Description
Blood pressure regulation is known to be maintained by a neuro-endocrine circuit, but whether immune cells contribute to blood pressure homeostasis has not been determined. We previously showed that CD4+ T lymphocytes that express choline acetyltransferase (ChAT), which catalyzes the synthesis of the vasorelaxant acetylcholine, relay neural signals. Here we show that these CD4 +CD44hiCD62L lo T helper...
- Subject
-
Blood PressureCD4-Positive T-LymphocytesCholine O-AcetyltransferaseHemostasis
- Access Rights
- Free to All
- Local Expert
- Peder Olofsson
-
IRF5 genetic risk variants drive myeloid-specific IRF5 hyper-activation and pre-symptomatic SLE
Internal Dataset- Authors
- Dan LiBharati MattaSu SongVictoria Nelson5 more author(s)...
- Description
The IRF5-SLE risk haplotype is associated with SLE disease severity. We hypothesized that neutrophils from healthy risk donors would carry a pathogenic gene signature compared to non-risk donors. To compare basal neutrophil gene signature between risk and non-risk healthy individuals, fresh whole blood was collected from healthy donors, and granulocytes were extracted from the remaining pellet following...
- Subject
-
Genetic Predisposition to DiseaseGenetic VariationInterferon Regulatory FactorsLupus Erythematosus, Systemic
- Access Rights
- Free to All
- Local Expert
- Betsy BarnesPeter Gregersen
-
Mortality in association with antipsychotic medication use and clinical outcomes among geriatric psychiatry outpatients with COVID-19
Internal Dataset- Authors
- Bienvenida AustriaRehana HaqueSukriti MittalJamie Scott5 more author(s)...
- Description
Includes both deidentified individual patient data and analysis outputs. Study included 56 patients. Demographic and clinical data including medication, diagnosis and Clinical Global Impression Severity (CGI-S) scales on outpatients who had COVID-19 between February 28th and October 1st 2020 were extracted from the electronic health records (EHR) from the hospital. Study observed a higher COVID-19...
- Subject
-
Antipsychotic AgentsCOVID-19Mental DisordersOutpatients
- Access Rights
- Free to All
- Local Expert
- Bienvenida AustriaYun Freudenberg-Hua
-
Single-cell analysis of menstrual endometrial tissues defines phenotypes associated with endometriosis
Internal Dataset- Authors
- Andrew ShihRobert AdelsonHimanshu VashisthaHouman Khalili10 more author(s)...
- Description
Background. Endometriosis is a common, complex disorder which is underrecognized and subject to prolonged delays in diagnosis. It is accompanied by significant changes in the eutopic endometrial lining. Methods. We have undertaken the first single cell RNA-sequencing (scRNA-Seq) comparison of endometrial tissues in freshly collected menstrual effluent (ME) from 33 subjects, including confirmed endometriosis...
- Subject
-
EndometriosisSingle-Cell Analysis
- Access Rights
- Free to All
- Local Expert
- Andrew ShihChristine MetzPeter Gregersen
-
Identification of grade and origin specific cell populations in serous epithelial ovarian cancer by single cell RNA-seq
Internal Dataset- Authors
- Andrew ShihAndrew MenzinJill WhyteJohn Lovecchio5 more author(s)...
- Description
Here we investigated different cell populations within ovarian cancer using single-cell RNA seq: fourteen samples from nine patients with differing grades (high grade, low grade and benign) as well as different origin sites (primary and metastatic tumor site, ovarian in origin and fallopian in origin).
- Subject
-
CancerCarcinoma, Ovarian EpithelialOvarian NeoplasmsRNA-SeqSequence Analysis, RNA
- Access Rights
- Free to All
- Local Expert
- Andrew ShihAnnette LeePeter Gregersen
-
Genome-wide analysis of M1 and M2 polarized macrophages with CNI-1493 treatment
Internal Dataset- Authors
- Anthony HeskethCaroline MaloneyChristopher BehrMorris Edelman5 more author(s)...
- Description
The purpose of this microarray is to identify genes that may be differentially expressed in M1 or M2 macrophages after treatment with CNI-1493. CNI-1493 is a known inhibitor of M1 macrophages but details of its molecular mechanism are unknown. The effect of CNI-1493 on M2 macrophages has yet to be explored, but we hypothesize that CNI-1493 treatment will attenuate pro-tumor properties of M2 macrophages....
- Subject
-
CancerGenomicsmice
- Access Rights
- Free to All
- Local Expert
- Bettie Steinberg
-
A Phase 3b, Multicenter, Prospective, Randomized, Double Blind, Placebocontrolled Study to Reduce Incidence of Pre-dialysis Hyperkalemia With Sodium Zirconium Cyclosilicate (DIALIZE)
Internal Dataset- Alternate Title(s)
- DIALIZE
- Authors
- Steven FishbaneMartin FordMasafumi FukagawaKieran McCafferty8 more author(s)...
- Description
Patients with ESRD receiving chronic hemodialysis often have persistent predialysis hyperkalemia. In the DIALIZE randomized study, the authors evaluated treatment with the potassium binder sodium zirconium cyclosilicate versus placebo in managing hyperkalemia in such patients. The authors report that compared with placebo, sodium zirconium cyclosilicate (SZC) significantly increased the proportion...
- Subject
-
Clinical TrialHyperkalemiaKidney
- Access Rights
- Free to AllApplication Required
- Local Expert
- Steven Fishbane
-
Renal circadian rhythm dysregulation in lupus nephritis
Internal Dataset- Authors
- Rakesh MishraRamalingam BethunaickanCeline BerthierZhengzi Yi4 more author(s)...
- Description
This study examines the circadian gene expression of whole kidneys of young and nephritic NZB/W F1 mice. Young mice were harvested at 12 weeks of age. Nephritic mice were harvested 2-3 weeks after nephritis onset (>300mg/dl proteinuria) but before the development of endstage renal failure (BUN >25). Remission was induced in nephritic mice with new onset proteinuria of less than 1 week duration measured...
- Subject
-
Lupus NephritismiceRNA-Seq
- Access Rights
- Free to All
- Local Expert
- Anne DavidsonPatricio Huerta
Filter by
Subject Domain
- Cancer 2
- RNA-Seq 2
- mice 2
- Antipsychotic Agents 1
- Blood Pressure 1
- CD4-Positive T-Lymphocytes 1
- COVID-19 1
- Carcinoma, Ovarian Epithelial 1
- Choline O-Acetyltransferase 1
- Clinical Trial 1
- Endometriosis 1
- Genetic Predisposition to Disease 1
- Genetic Variation 1
- Genomics 1
- Hemostasis 1
- Hyperkalemia 1
- Interferon Regulatory Factors 1
- Kidney 1
- Lupus Erythematosus, Systemic 1
- Lupus Nephritis 1
- Mental Disorders 1
- Outpatients 1
- Ovarian Neoplasms 1
- Sequence Analysis, RNA 1
- Single-Cell Analysis 1