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Results Found: 9

  • Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase
    Internal Dataset

    Authors
    Peder Olofsson
    Michaela Oswald
    Kevin Tracey
    Description

    Blood pressure regulation is known to be maintained by a neuro-endocrine circuit, but whether immune cells contribute to blood pressure homeostasis has not been determined. We previously showed that CD4+ T lymphocytes that express choline acetyltransferase (ChAT), which catalyzes the synthesis of the vasorelaxant acetylcholine, relay neural signals. Here we show that these CD4 +CD44hiCD62L lo T helper...

    Subject
    Blood Pressure
    CD4-Positive T-Lymphocytes
    Choline O-Acetyltransferase
    Hemostasis
    Access Rights
    Free to All
    Local Expert
    Peder Olofsson

  • Genome-wide analysis of M1 and M2 polarized macrophages with CNI-1493 treatment
    Internal Dataset

    Authors
    Anthony Hesketh
    Caroline Maloney
    Christopher Behr
    Morris Edelman
    5 more author(s)...
    Description

    The purpose of this microarray is to identify genes that may be differentially expressed in M1 or M2 macrophages after treatment with CNI-1493. CNI-1493 is a known inhibitor of M1 macrophages but details of its molecular mechanism are unknown. The effect of CNI-1493 on M2 macrophages has yet to be explored, but we hypothesize that CNI-1493 treatment will attenuate pro-tumor properties of M2 macrophages....

    Subject
    Cancer
    Genomics
    mice
    Access Rights
    Free to All
    Local Expert
    Bettie Steinberg

  • RNA-seq of DRG neurons isolated from alum vs. alum+KLH immunized mice
    Internal Dataset

    Authors
    Manojkumar Gunasekaran
    Prodyot Chatterjee
    Andrew Shih
    Gavin Imperato
    18 more author(s)...
    Description

    Using a combination of rigorous molecular genetic analyses, transgenic mice, and adoptive transfer experiments, we demonstrate that DRGs do not synthesize these antigen-specific antibodies, but rather sequester primarily IgG1 subtype antibodies. As revealed by RNA-seq and targeted quantitative PCR (qPCR), dorsal root ganglion (DRG) sensory neurons harvested from either naïve or immunized mice lack...

    Subject
    Antibodies
    Ganglia, Spinal
    Inflammation
    RNA-Seq
    Sensory Receptor Cells
    Sequence Analysis, RNA
    Access Rights
    Free to All
    Local Expert
    Andrew Shih
    Sangeeta Chavan

  • Blood-brain barrier deterioration and hippocampal gene expression in polymicrobial sepsis: an evaluation of endothelial MyD88 and the vagus nerve
    Internal Dataset

    Authors
    Gerard Honig
    Simone Mader
    Huiyi Chen
    Amit Porat
    4 more author(s)...
    Description

    Systemic infection can initiate or exacerbate central nervous system (CNS) pathology, even in the absence of overt invasion of bacteria into the CNS. Recent epidemiological studies have demonstrated that human survivors of sepsis have an increased risk of long-term neurocognitive decline. There is thus a need for improved understanding of the physiological mechanisms whereby acute sepsis affects the...

    Subject
    mice
    Vagus Nerve
    Access Rights
    Free to All
    Local Expert
    Betty Diamond
    Bruce Volpe

  • Murine follicular helper T cells
    Internal Dataset

    Authors
    Vera Kim
    Kyungwoo Lee
    Hong Tian
    Su Hwa Jang
    2 more author(s)...
    Description

    Follicular Th (Tfh) cells are key CD4+ Th cells involved in regulating B cell differentiation in the germinal center. Mice with conditional KO (CKO) of B lymphocyte-induced maturation protein-1 (BLIMP-1) expression in CD11chi DCs (Prdm1 CKO) spontaneously develop a lupus-like disease. We found an increase in the number of Tfh cells in secondary lymphoid organs in lupus-prone Prdm1-CKO mice. B cells...

    Subject
    Autoimmunity
    Lupus Nephritis
    Lymphocyte Activation
    Access Rights
    Free to All
    Local Expert
    Sun Jung Kim

  • Renal circadian rhythm dysregulation in lupus nephritis
    Internal Dataset

    Authors
    Rakesh Mishra
    Ramalingam Bethunaickan
    Celine Berthier
    Zhengzi Yi
    4 more author(s)...
    Description

    This study examines the circadian gene expression of whole kidneys of young and nephritic NZB/W F1 mice. Young mice were harvested at 12 weeks of age. Nephritic mice were harvested 2-3 weeks after nephritis onset (>300mg/dl proteinuria) but before the development of endstage renal failure (BUN >25). Remission was induced in nephritic mice with new onset proteinuria of less than 1 week duration measured...

    Subject
    Lupus Nephritis
    mice
    RNA-Seq
    Access Rights
    Free to All
    Local Expert
    Anne Davidson
    Patricio Huerta

  • Extracellular CIRP Induces an Inflammatory Phenotype in Pulmonary Fibroblasts via TLR4
    Internal Dataset

    Authors
    Siavash Bolourani
    Ezgi Sari
    Max Brenner
    Ping Wang
    Description

    In order to study the connection of the enrichment of these pathways in priming the microenvironment for pulmonary fibrosis, we investigated the gene expression profile of lung tissues from mice subjected to bleomycin-induced pulmonary fibrosis. The wild type (WT) and TLR4 -/- pulmonary fibroblasts were treated with phosphate-buffered saline (PBS), 1 µg/mL recombinant mouse (rm) CIRP, 2 ng/mL rmTGF-ß1...

    Subject
    Fibroblasts
    Inflammation
    mice
    Pulmonary Fibrosis
    Access Rights
    Free to All
    Local Expert
    Max Brenner
    Ping Wang

  • The role of eCIRP in bleomycin-induced pulmonary fibrosis in mice
    Internal Dataset

    Authors
    Siavash Bolourani
    Ezgi Sari
    Max Brenner
    Ping Wang
    Description

    We examined the role of eCIRP in the pathogenesis of bleomycin-induced pulmonary fibrosis (PF). Publicly available gene expression omnibus datasets were analyzed for the expression of CIRP in lung samples from patients with PF. Wild type (WT) or CIRP-/- mice received daily injections of 10 μg/g bleomycin for 10 days. A subset of bleomycin-injected WT mice was treated with the eCIRP antagonist C23 (8...

    Subject
    mice
    MicroRNAs
    Pulmonary Fibrosis
    Access Rights
    Free to All
    Local Expert
    Max Brenner
    Ping Wang

  • Autoantigen promotes progression to aggressive TCL1 leukemia
    Internal Dataset

    Authors
    Shih-­Shih Chen
    Franak Batliwalla
    Nichol Holodick
    Xiao-Jie Yan
    4 more author(s)...
    Description

    (Auto)antigen engagement by the B-cell receptor (BCR) and possibly the sites where this occurs influence the outcome of chronic lymphocytic leukemia (CLL). To test if selection for autoreactivity leads to increased aggressiveness and if this selection plays out equally in primary and secondary tissues, we used T-cell leukemia (TCL)1 cells reactive with the autoantigen phosphatidylcholine (PtC). After...

    Subject
    Genomics
    Leukemia
    Selection, Genetic
    Access Rights
    Free to All
    Local Expert
    Nicholas Chiorazzi
    Shih-­Shih Chen