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Results Found: 5

  • Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase
    Internal Dataset

    Authors
    Peder Olofsson
    Michaela Oswald
    Kevin Tracey
    Description

    Blood pressure regulation is known to be maintained by a neuro-endocrine circuit, but whether immune cells contribute to blood pressure homeostasis has not been determined. We previously showed that CD4+ T lymphocytes that express choline acetyltransferase (ChAT), which catalyzes the synthesis of the vasorelaxant acetylcholine, relay neural signals. Here we show that these CD4 +CD44hiCD62L lo T helper...

    Subject
    Blood Pressure
    CD4-Positive T-Lymphocytes
    Choline O-Acetyltransferase
    Hemostasis
    Access Rights
    Free to All
    Local Expert
    Peder Olofsson

  • IRF5 genetic risk variants drive myeloid-specific IRF5 hyper-activation and pre-symptomatic SLE
    Internal Dataset

    Authors
    Dan Li
    Bharati Matta
    Su Song
    Victoria Nelson
    5 more author(s)...
    Description

    The IRF5-SLE risk haplotype is associated with SLE disease severity. We hypothesized that neutrophils from healthy risk donors would carry a pathogenic gene signature compared to non-risk donors. To compare basal neutrophil gene signature between risk and non-risk healthy individuals, fresh whole blood was collected from healthy donors, and granulocytes were extracted from the remaining pellet following...

    Subject
    Genetic Predisposition to Disease
    Genetic Variation
    Interferon Regulatory Factors
    Lupus Erythematosus, Systemic
    Access Rights
    Free to All
    Local Expert
    Betsy Barnes
    Peter Gregersen

  • Mortality in association with antipsychotic medication use and clinical outcomes among geriatric psychiatry outpatients with COVID-19
    Internal Dataset

    Authors
    Bienvenida Austria
    Rehana Haque
    Sukriti Mittal
    Jamie Scott
    5 more author(s)...
    Description

    Includes both deidentified individual patient data and analysis outputs. Study included 56 patients. Demographic and clinical data including medication, diagnosis and Clinical Global Impression Severity (CGI-S) scales on outpatients who had COVID-19 between February 28th and October 1st 2020 were extracted from the electronic health records (EHR) from the hospital. Study observed a higher COVID-19...

    Subject
    Antipsychotic Agents
    COVID-19
    Mental Disorders
    Outpatients
    Access Rights
    Free to All
    Local Expert
    Bienvenida Austria
    Yun Freudenberg-Hua

  • RNA-seq of DRG neurons isolated from alum vs. alum+KLH immunized mice
    Internal Dataset

    Authors
    Manojkumar Gunasekaran
    Prodyot Chatterjee
    Andrew Shih
    Gavin Imperato
    18 more author(s)...
    Description

    Using a combination of rigorous molecular genetic analyses, transgenic mice, and adoptive transfer experiments, we demonstrate that DRGs do not synthesize these antigen-specific antibodies, but rather sequester primarily IgG1 subtype antibodies. As revealed by RNA-seq and targeted quantitative PCR (qPCR), dorsal root ganglion (DRG) sensory neurons harvested from either naïve or immunized mice lack...

    Subject
    Antibodies
    Ganglia, Spinal
    Inflammation
    RNA-Seq
    Sensory Receptor Cells
    Sequence Analysis, RNA
    Access Rights
    Free to All
    Local Expert
    Andrew Shih
    Sangeeta Chavan

  • A Phase 3b, Multicenter, Prospective, Randomized, Double Blind, Placebocontrolled Study to Reduce Incidence of Pre-dialysis Hyperkalemia With Sodium Zirconium Cyclosilicate (DIALIZE)
    Internal Dataset

    Alternate Title(s)
    DIALIZE
    Authors
    Steven Fishbane
    Martin Ford
    Masafumi Fukagawa
    Kieran McCafferty
    8 more author(s)...
    Description

    Patients with ESRD receiving chronic hemodialysis often have persistent predialysis hyperkalemia. In the DIALIZE randomized study, the authors evaluated treatment with the potassium binder sodium zirconium cyclosilicate versus placebo in managing hyperkalemia in such patients. The authors report that compared with placebo, sodium zirconium cyclosilicate (SZC) significantly increased the proportion...

    Subject
    Clinical Trial
    Hyperkalemia
    Kidney
    Access Rights
    Free to All
    Application Required
    Local Expert
    Steven Fishbane