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Results Found: 2

  • IRF5 genetic risk variants drive myeloid-specific IRF5 hyper-activation and pre-symptomatic SLE
    Internal Dataset

    Authors
    Dan Li
    Bharati Matta
    Su Song
    Victoria Nelson
    5 more author(s)...
    Description

    The IRF5-SLE risk haplotype is associated with SLE disease severity. We hypothesized that neutrophils from healthy risk donors would carry a pathogenic gene signature compared to non-risk donors. To compare basal neutrophil gene signature between risk and non-risk healthy individuals, fresh whole blood was collected from healthy donors, and granulocytes were extracted from the remaining pellet following...

    Subject
    Genetic Predisposition to Disease
    Genetic Variation
    Interferon Regulatory Factors
    Lupus Erythematosus, Systemic
    Access Rights
    Free to All
    Local Expert
    Betsy Barnes
    Peter Gregersen

  • Rare Variants and HLA Haplotypes Associated in Serbian Patients with Neuromyelitis Optica Spectrum Disorders
    Internal Dataset

    Authors
    Inna Tabansky
    Akemi Tanaka
    Jiayao Wang
    Guanglan Zhang
    23 more author(s)...
    Description

    Neuromyelitis optica spectrum disorders (NMOSD) are rare, debilitating, antibody-mediated autoimmune diseases of the central nervous system. Prior studies show associations of NMOSD with individual Human Leukocyte Antigen (HLA) alleles and the complement pathway. HLA allele associations with NMOSD are inconsistent between populations, suggesting complex relationships between the identified alleles...

    Subject
    Autoimmunity
    HLA Antigens
    Neuromyelitis Optica
    Retrospective Studies
    Access Rights
    Free to All
    Application Required
    Local Expert
    Joel Stern