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Results Found: 2

  • Investigations into SCAMP5, a candidate lupus risk gene expressed in plasmacytoid dendritic cells
    Internal Dataset

    Authors
    Mustafa Ghanem
    Andrew Shih
    Himanshu Vashistha
    Latanya Coke
    4 more author(s)...
    Description

    Objective: We have investigated the molecular function of SCAMP5, a candidate risk gene for SLE exclusively expressed in plasmacytoid dendritic cells (pDCs) among peripheral leucocytes. Methods: We tested the independence of the association in SCAMP5 with SLE by performing conditional analyses. We profiled the expression pattern of SCAMP5 among circulating leucocytes at the transcript and protein...

    Subject
    Dendritic Cells
    Lupus Erythematosus, Systemic
    Membrane Proteins
    RNA-Seq
    Access Rights
    Free to All
    Local Expert
    Andrew Shih
    Peter Gregersen

  • IRF5 genetic risk variants drive myeloid-specific IRF5 hyper-activation and pre-symptomatic SLE
    Internal Dataset

    Authors
    Dan Li
    Bharati Matta
    Su Song
    Victoria Nelson
    5 more author(s)...
    Description

    The IRF5-SLE risk haplotype is associated with SLE disease severity. We hypothesized that neutrophils from healthy risk donors would carry a pathogenic gene signature compared to non-risk donors. To compare basal neutrophil gene signature between risk and non-risk healthy individuals, fresh whole blood was collected from healthy donors, and granulocytes were extracted from the remaining pellet following...

    Subject
    Genetic Predisposition to Disease
    Genetic Variation
    Interferon Regulatory Factors
    Lupus Erythematosus, Systemic
    Access Rights
    Free to All
    Local Expert
    Betsy Barnes
    Peter Gregersen

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