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Genome-wide analysis of M1 and M2 polarized macrophages with CNI-1493 treatment
Internal Dataset- Authors
- Anthony HeskethCaroline MaloneyChristopher BehrMorris Edelman5 more author(s)...
- Description
The purpose of this microarray is to identify genes that may be differentially expressed in M1 or M2 macrophages after treatment with CNI-1493. CNI-1493 is a known inhibitor of M1 macrophages but details of its molecular mechanism are unknown. The effect of CNI-1493 on M2 macrophages has yet to be explored, but we hypothesize that CNI-1493 treatment will attenuate pro-tumor properties of M2 macrophages....
- Subject
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CancerGenomicsmice
- Access Rights
- Free to All
- Local Expert
- Bettie Steinberg
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Blood-brain barrier deterioration and hippocampal gene expression in polymicrobial sepsis: an evaluation of endothelial MyD88 and the vagus nerve
Internal Dataset- Authors
- Gerard HonigSimone MaderHuiyi ChenAmit Porat4 more author(s)...
- Description
Systemic infection can initiate or exacerbate central nervous system (CNS) pathology, even in the absence of overt invasion of bacteria into the CNS. Recent epidemiological studies have demonstrated that human survivors of sepsis have an increased risk of long-term neurocognitive decline. There is thus a need for improved understanding of the physiological mechanisms whereby acute sepsis affects the...
- Subject
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miceVagus Nerve
- Access Rights
- Free to All
- Local Expert
- Betty DiamondBruce Volpe
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