Internal Dataset
NBQX disodium salt, an AMPA receptor antagonist, is used for an in vitro treatment of human smooth muscle cells
UID: 10384
- Description
- Vascular smooth muscle cells (VSMCs) are key constituents of both normal arteries and atherosclerotic plaques. They have an ability to adapt to changes in the local environment by undergoing phenotypic modulation. The amino-acid glutamate has been associated with CVD risk and VSMCs metabolism in experimental vascular research, and glutamate receptors regulate VSMC biology and promote pulmonary vascular remodeling. In vitro, human carotid artery SMCs expressed AMPA- type receptors, and selective AMPA-type receptor blocking inhibited expression of typical contractile markers and promoted pathways associated with VSMC phenotypic modulation.
- Local Expert
Access
- Restrictions
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Free to All
- Instructions
- The European Nucleotide Archive (ENA) is an open, supported platform for the management, sharing, integration, archiving and dissemination of sequence data. ENA comprises both the globally comprehensive data resource that preserves the world’s public-domain output of sequence data and a rich portfolio of tools and services to support the management of sequence data.
7900 HT Fast Real-Time PCR
- Grant Support
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20140212/Knut and Alice Wallenberg Foundation2017-03366/Swedish Research Council20170708, 20170880/Swedish Heart-Lung Foundation
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