Patients with ESRD receiving chronic hemodialysis often have persistent predialysis hyperkalemia. In the DIALIZE randomized study, the authors evaluated treatment with the potassium binder sodium zirconium cyclosilicate versus placebo in managing hyperkalemia in such patients. The authors report that compared with placebo, sodium zirconium cyclosilicate (SZC) significantly increased the proportion...

AACR Project GENIE is a publicly accessible international cancer registry of real-world data assembled through data sharing between 19 of the leading cancer centers in the world. Through the efforts of strategic partners Sage Bionetworks and cBioPortal, the registry aggregates, harmonizes, and links clinical-grade, next-generation cancer genomic sequencing data with clinical outcomes obtained during...

The AMA Physician Masterfile includes education, training and professional certification information on virtually all Doctors of Medicine (MD) and Doctors of Osteopathic Medicine (DO) in the United States, Puerto Rico, Virgin Islands, and certain Pacific Islands. It includes current and historical data for more than 1.4 million physicians, residents, and medical students in the United States. This...

ACCORD was a large clinical trial examining methods of lowering the rate of cardiovascular disease in adults with type two diabetes. The study was composed of three clinical trials: an intensive lowering of blood sugar levels, intensive lowering of blood pressure, and treatment of multiple blood lipids with a combination of a fibrate and a statin. The study enrolled 10,251 adults beginning in 2001.

The Acute Stroke Database is a REDCAP database based off of the Get With the Guidelines (GWTG) stroke program. The database contains data on all stroke patients 18+ who came to North Shore University Hospital, which is a comprehensive stroke center (CSC). As a CSC, stroke patients from outside hospitals would transfer in for advanced care in both hemorrhagic and ischemic stroke. The database contains...

Performing Comprehensive-CT (NCCT+CTA+CTP) at initial presentation in patients presenting with suspected acute ischemic stroke in the anterior circulation with last-known-well-to-arrival time 0–24 hours at comprehensive stroke centers is cost-effective compared to Comprehensive-MR and stepwise approaches. We have created a simplified depiction of the decision model demonstrating the imaging-based algorithmic...

The All of Us Research Program is part of an effort to advance individualized health care by enrolling one million or more participants to contribute their health data over many years. The program aims to reflect the diversity of the United States and to include participants from groups that have been underrepresented in health research in the past. The program is developing custom tools and software...

In this study we sought to analyze the effects of genetic variants on gene regulation in a cell-state dependent manner during CD4 memory T cell activation. To do this, we performed an RNA-seq time series experiment on CD4 memory T cells activated with anti-CD3/CD28 beads in individuals with no autoimmune disease. We measured gene expression levels, and allele-specific expression at heterozygous sites...

The American Community Survey (ACS) is an ongoing survey that provides data every year -- giving communities the current information they need to plan investments and services. Information from the survey generates data that help determine how more than $400 billion in federal and state funds are distributed each year. To help communities, state governments, and federal programs, we ask about: age,...

The American Time Use Survey (ATUS) provides nationally representative estimates of how, where, and with whom Americans spend their time, and is the only federal survey providing data on the full range of nonmarket activities, from childcare to volunteering.